Type 3 Diabetes?
Monday, March 7th, 2005Now things are really getting exotic. Alzheimer’s is really type 3 diabetes? Veddy veddy interesting. But you know, I’ve done quite a bit of work covering studies related to the causes of Alzheimer’s, and there are so many different theories. I tend to think that the riddle of Alzheimer’s has many answers, which makes it all that much more difficult to solve.
Two potentially significant discoveries about insulin may shed new light on how Alzheimer’s disease ravages the brain, and might one day lead to new treatments.
The first discovery is that insulin is produced in the brain; the second is that Alzheimer’s patients have impaired insulin production in their brains.
“Insulin is made in the brain. Previously it was thought to be made only in the pancreas,” said lead researcher Dr. Suzanne de la Monte, an associate professor of pathology and medicine at Brown University. “In Alzheimer’s disease, the production of insulin in the brain is substantially reduced.”
In experiments with rats, de la Monte’s team found insulin is produced in several areas of the brain. The researchers also discovered that reducing the production of insulin in the animals’ brains added to the deterioration of brain cells, an early sign of Alzheimer’s.
When de la Monte’s team looked at brain tissue from deceased Alzheimer’s patients, they found that insulin production was severely curtailed in areas of the brain affected by Alzheimer’s.
Here’s the link to the rest of the story